Calibration

Instrument calibration is the process of adjusting and verifying the performance of a measurement instrument to ensure its accuracy and precision. The goal is to align the instrument’s output with a known standard or reference.This process typically involves:

 

  1. Comparison with Standards

Measuring known reference materials or standards to check if the instrument’s readings match the expected values.

  1. Adjustment

Making necessary adjustments to the instrument to correct any discrepancies between its output and the known standards.

  1. Documentation

Recording the calibration process, including the standards used, adjustments made, and the instrument’s performance.

  1. Verification

Periodically repeating the calibration process to ensure continued accuracy and reliability.

 

Calibration is essential for maintaining the accuracy of measurements and ensuring consistent, reliable results across different instruments and measurement sessions.

 

Instrument calibration is essential for several reasons:

 

  1. Accuracy

Ensures that measurements taken by the instrument are correct and reflect true values, which is crucial for reliable results and data integrity.

  1. Consistency

Helps maintain consistency across different instruments and measurement sessions, ensuring that results are comparable and reproducible.

  1. Compliance

Meets regulatory and industry standards that require regular calibration for equipment used in critical applications, such as in laboratories, manufacturing, and medical diagnostics.

  1. Performance Maintenance

Identifies and corrects drift or errors in the instrument’s performance, extending its lifespan and preventing potential failures.

  1. Quality Control

Supports the quality assurance processes by ensuring that instruments provide precise measurements, which is essential for maintaining high standards in research, production, and diagnostics.

 

Calibration should be performed in the following situations:

 

  1. Initial Setup

When the instrument is first installed or set up, to ensure it operates correctly from the beginning.

  1. Routine Maintenance

According to the manufacturer’s recommendations or standard operating procedures, which often suggest periodic calibration.

  1. Post-Maintenance

After significant repairs or parts replacements, to confirm the instrument’s accuracy after adjustments.

  1. Before Critical Measurements

Before conducting important or high-stakes measurements to ensure accuracy and reliability.

  1. When Performance Deviates

If there is any indication that the instrument is giving inconsistent or inaccurate readings, calibration is needed to rectify the issue.

  1. Regulatory Requirements

To comply with industry standards and regulatory guidelines, which may mandate specific calibration intervals or procedures.

 

Regular and timely calibration helps maintain the instrument’s accuracy, reliability, and overall performance.

 

Instrumen list

What instruments need instrument calibration?

  1. 7500/7500 Fast Real-Time PCR
  2. QuantStudio Family Real-Time PCR
  3. Genetic Analyzer
  4. NGS
  5. Microcentrifuge
  6. Chromatography
  7.  Cole Palmer Homogenizer

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