mRNA Resin

Rp20

The Thermo Scientificâ„¢ POROSâ„¢ Oligo (dT) 25 Affinity Resin is designed for the purification and isolation of mRNA from in vitro transcription (IVT) manufacturing processes. The use of affinity chromatography offers high selectivity and ease of use. Through the AT-base pairing mechanism, the resin effectively separates mRNA from components of the transcription reaction process, such as enzymes, unreacted nucleotides, partial transcripts and plasmid DNA.

Clear

POROS Oligo (dT)25 Affinity Resin was developed to address the selectivity and capacity requirements for large-scale downstream purification of a range of mRNA constructs used in vaccine and gene therapy applications. Unlike alternate approaches, the resin selectively captures the mRNA via the polyadenylated (polyA) tail using simple salt and water purification steps.

class

Chromatography Resin

applications

product-type

Consumable

Features & Benefits

Features of POROS Oligo (dT)25 Affinity Resin include:

Easy mRNA purification from crude transcription mix to effectively remove plasmid DNA and other IVT components
Simplified workflow helps to maximize efficiency, thereby reducing complexity of subsequent polish steps
Excellent scalability
Non-animal derived

Specifications

Official Website

mRNA Resin – Official Website

Brochures

mRNA Resin – Brochures